Öлª¸ÎÔಡÔÓÖ¾2016Äê3ÔµÚ24¾íµÚ3ÆÚChinJHepatol£¬March2016£¬V01£®24£¬No£®3
¡¤×¨¼Ò÷롤
±ûÐ͸ÎÑ×Ö±½Ó¿¹²¡¶¾Ò©ÎïÁÙ´²ÊÔÑéÆÀ¼Ûר¼Ò½¨Òé
¹ú¼Ò¡°ÖØ´óÐÂÒ©´´ÖÆ¡±¿Æ¼¼ÖØ´óרÏî¡°ÖØ´ó¼²²¡ÐÂÒ©ÁÙÀ´ÆÀ¼ÛÑо¿×ۺϼ¼Êõƽ̨½¨É衱¿ÎÌâϸ
ͨÐÅ×÷Õߣº·¶Ñ§¹¤£¬Email£ºxgfan57@126£®com£¬410008³¤É³£¬ÖÐÄÏ´óÑ§ÏæÑÅÒ½Ôº¸ÐȾ²¡¿Æ
DOI£º10£®370Ycnnj¡£iss¡¾L100¡Þ418£®2016£®03£®001
¡¾¹Ø¼ü´Ê¡¿¸ÎÑײ¡¶¾£¬±ûÐÍ£» Ö±½Ó¿¹²¡¶¾Ò©Î ÁÙ´²ÊÔÑé
»ù½ðÏîÄ¿£º¹ú¼ÒÖØ´ó¿Æ¼¼×¨Ïî(2012ZX09303014)
Expertadvicesfor
evaluating
clinicaltrialsofdirect-actingantJviròÄagentsforhepatitisCResearch
Groupfor
NewDrug'sClinicalEvalutaionofCriticalDiseasesandPlatformConstructionofIntegratedTechnology
Corresponding
author£ºFan
Xuegong,Email£ºxgfan57@126£®com£¬XiangyaHospital,Central
South
University,
Changsha41000&China
[Keywords]Hepatitis
C
virus£»Direct-acting
antiviral
agents£»Clinical
trial
Fund
program£ºNational
Scienceand
TechnologyMajorProjects(2012ZX09303014)
½üÄêÀ´£¬±ûÐ͸ÎÑ×Ö±½Ó¿¹²¡¶¾Ò©Îï(direct-acting
antiviralagents£¬DAA)µÄÑо¿¿ª·¢ÒѽøÈë¿ìËÙ·¢
Õ¹½×¶Î£¬²»¶ÏÓÐÐÂÒ©»ñ×¼ÉÏÊС£DAAµÄ³öÏÖ¶ÔÓÚ
±ûÐ͸ÎÑ×µÄÖÎÁƾßÓл®Ê±´úµÄÒâÒ壬Ëü²»½öÌá¸ß
Á˱ûÐ͸ÎÑ×µÄÖÎÁÆÐ§¹û£¬»¹ÓпÉÄÜÈ¡´ú¸ÉÈÅËØ½ö
(interferon-alpha£¬IFN0¡¾)£¬³ÉΪһÖÖеıê×¼ÖÎÁÆ¡£
Ŀǰ¹úÄÚÒÑÓÐÔ½À´Ô½¶àµÄÁÙ´²Ò½Ê¦ºÍÒ½ÁƵ¥Î»ÔÚ²»
ͬ³Ì¶ÈÉϲÎÓëDAAµÄÒ©ÎïÁÙ´²ÊÔÑ鹤×÷£¬µ«¹úÄÚÉÐ
ÎÞÏà¹ØÖ¸ÄÏ»ò¹æ·¶£¬ÎªÊ¹Õâ·½ÃæµÄ¹¤×÷¸ü¹æ·¶¡¢¸ü
·ûºÏ¹úÄÚÐÂÒ©ÆÀ¼ÛµÄÒªÇó²¢Óë¹ú¼Ê½Ó¹ì£¬ÎÒÃÇ×éÖ¯
Á˹úÄÚ²¿·ÖÖªÃûר¼Ò£¬¾Í±ûÐ͸ÎÑ×DAAµÄÐÂÒ©ÁÙ´²
ÊÔÑéµÄÏà¹ØÎÊÌâ½øÐÐÁ˹㷺ÌÖÂÛ£¬²¢²Î¿¼¹úÄÚÍâÏà
¹ØÎÄÏ×£¬ÐγÉÁË¡¶±ûÐ͸ÎÑ×Ö±½Ó¿¹²¡¶¾Ò©ÎïÁÙ´²ÊÔ
ÑéÆÀ¼Ûר¼Ò½¨Òé¡·(ÒÔϼò³Æ((½¨Òé¡·)¡£
±¾¡¶½¨Òé))ÊÇ»ùÓÚĿǰÂýÐÔ±ûÐ͸ÎÑ׿¹²¡¶¾(HCV)
ÖÎÁƵÄ×îгɹû£¬×ñÕÕÑ֤ҽѧµÄÔÔò±àд£¬Ö÷ÒªÕë
¶ÔII¡¢IIIÆÚÒ©ÎïÁÙ´²ÊÔÑé£¬Ëæ×ÅÏà¹ØÁÙ´²Ö¤¾ÝµÄ²»¶Ï
»ýÀÛ£¬×¨¼ÒίԱ»á½«¶Ô¡¶½¨Òé¡·ÄÚÈݽøÐиüС£
DAAÓÖ³ÆHCVÌØÒìÐÔ°ÐÏò¿¹²¡¶¾ÖÎÁÆÒ©ÎÕâ
ЩҩÎïÌØÒìÐÔ×÷ÓÃÓÚHCV¸´ÖÆÖÜÆÚ¡£¸ù¾ÝÒ©Îï×÷
Óò¿Î»£¬¿É·ÖΪNS3£¯4Aµ°°×øÒÖÖÆ¼Á¡¢NS5Aµ°°×
øÒÖÖÆ¼Á¡¢ºËÜÕÀàÓë·ÇºËÜÕÀàNS5Bµ°°×øÒÖÖÆ¼Á
ÓëÄÚ²¿ºËÌÇÌå½øÈëλµã(intemal
ribosome
entrysite£¬
IRES)ÒÖÖÆ¼ÁµÈ¡£
Ò»¡¢²¡ÀýÑ¡Ôñ(ÊÜÊÔÕßÌØÕ÷¼°Ñ¡Ôñ)
1£®ÂýÐÔ±ûÐ͸ÎÑ׵͍ÒåºÍÕï¶Ï±ê×¼£ºH
【肝病】丙型肝炎直接抗病毒药物临床试验评价专家建议.pdf